Cover Angew. Chem. Int. Ed

Angewandte Chemie International Edition features on its front cover the recently published research article “Harnessing the Structure and Dynamics of the Squalene-Hopene Cyclase for (?)-Ambroxide Production”, DOI: 10.1002/anie.202301607
Ambergris is a highly valued natural product in the fragrance industry and is also known as “floating gold” because of its biosynthesis in the intestines of sperm whales. Owing to this scarce natural resource, the stereoselective synthesis of its most prominent olfactory component, (?)-ambroxide, via alternative routes is attractive. In their Research Article (e202301607), Sílvia Osuna, Bernhard Hauer et?al. demonstrate the catalytic potential of an engineered squalene-hopene cyclase in the intricate cyclization of the precursor homofarnesol. Cover art: Verena Resch, Graz.